INTENDED USE

The PEDV IgA ab Test is a lateral flow immunochromatographic assay for the semi-quantitative detection of Porcine Epidemic Diarrhea Virus IgA (PEDV-IgA) in swine’s serum or plasma.

Introduction

Porcine epidemic diarrhea virus (PEDV), the etiological agent of PED (porcine epidemic diarrhea), is an approximately 28 kb, positive-sense, single-stranded, enveloped RNA virus, which is a member of the genus Alphacoronavirus in the family Coronaviridae of the order Nidovirales.
PEDV can infect pigs of all ages, causing watery diarrhea and vomiting accompanied by anorexia and depression. Morbidity approaches 100 % in piglets but can vary in sows. The incubation period of PEDV is approximately 2 days, ranging from 1 to 8 days depending on field conditions. The interval between the onset and cessation of clinical signs is 3 to 4 weeks.
The disease severities and mortality rates are inversely associated with the age of the pigs. The mortality rate averages 50 %, often approaching 100 % in 1- to 3-day-old piglets, and decreases to 10 % thereafter. In older animals, including weaner to finisher pigs, clinical signs are self-limiting within 1 week after the onset of the disease. The main means of PEDV transmission is the direct or indirect fecal-oral route. Fecal shedding of PEDV can be detected within 48 hours and may last for up to 4 weeks. Diarrheal feces and/or vomitus and other contaminated fomites, such as transport trailers and feed, can be major transmission sources of the virus. Asymptomatic infected older pigs can be a possible reservoir and carrier. PEDV can become airborne, remain contagious while suspended in the air, and the genetic material of the virus can be transported long distances following natural infections.